Successful Repeated Hepatic Gene Delivery in Mice and Non-human Primates Achieved by Sequential Administration of AAV5(ch) and AAV1

In the gene therapy field, re-administration of adeno-associated virus (AAV) is an important topic because a decrease in therapeutic protein expression might occur over time. However, an efficient re-administration with the same AAV serotype is impossible due to serotype-specific, anti-AAV neutraliz...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Majowicz, Anna, Salas, David, Zabaleta, Nerea, Rodríguez-Garcia, Estefania, González-Aseguinolaza, Gloria, Petry, Harald, Ferreira, Valerie
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542767/
https://ncbi.nlm.nih.gov/pubmed/28596114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.003
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