Rho Kinase Inhibition Is Essential During In Vitro Neurogenesis and Promotes Phenotypic Rescue of Human Induced Pluripotent Stem Cell-Derived Neurons With Oligophrenin-1 Loss of Function

Rho-GTPases have relevant functions in various aspects of neuronal development, such as differentiation, migration, and synaptogenesis. Loss of function of the oligophrenin-1 gene (OPHN1) causes X-linked intellectual disability with cerebellar hypoplasia and leads to hyperactivation of the rho kinas...

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Detalles Bibliográficos
Publicado en:Stem Cells Transl Med
Main Authors: Compagnucci, Claudia, Barresi, Sabina, Petrini, Stefania, Billuart, Pierre, Piccini, Giorgia, Chiurazzi, Pietro, Alfieri, Paolo, Bertini, Enrico, Zanni, Ginevra
Formato: Artigo
Idioma:Inglês
Publicado: AlphaMed Press 2016
Assuntos:
Pluripotent Stem Cells
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922854/
https://ncbi.nlm.nih.gov/pubmed/27160703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5966/sctm.2015-0303
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