Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation

The patho-physiological hypothesis of mental retardation caused by the deficiency of the RhoGAP Oligophrenin1 (OPHN1), relies on the well-known functions of Rho GTPases on neuronal morphology, i.e. dendritic spine structure. Here, we describe a new function of this Bin/Amphiphysin/Rvs domain contain...

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Hauptverfasser: Khelfaoui, Malik, Pavlowsky, Alice, Powell, Andrew D., Valnegri, Pamela, Cheong, Kenneth W., Blandin, Yann, Passafaro, Maria, Jefferys, John G.R., Chelly, Jamel, Billuart, Pierre
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2701329/
https://ncbi.nlm.nih.gov/pubmed/19401298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddp189
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