Loss of X-Linked Mental Retardation Gene Oligophrenin1 in Mice Impairs Spatial Memory and Leads to Ventricular Enlargement and Dendritic Spine Immaturity

Loss of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar hypoplasia and, in some cases, with lateral ventricle enlargement. In vitro studies showed that ophn1 regulates dendritic spine through the control of Rho GTPases, but its in vivo function r...

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Bibliografiska uppgifter
I publikationen:J Neurosci
Huvudupphovsmän: Khelfaoui, Malik, Denis, Cécile, van Galen, Elly, de Bock, Frédéric, Schmitt, Alain, Houbron, Christophe, Morice, Elise, Giros, Bruno, Ramakers, Ger, Fagni, Laurent, Chelly, Jamel, Nosten-Bertrand, Marika, Billuart, Pierre
Materialtyp: Artigo
Språk:Inglês
Publicerad: Society for Neuroscience 2007
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Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673114/
https://ncbi.nlm.nih.gov/pubmed/17728457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2029-07.2007
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