Loss of X-Linked Mental Retardation Gene Oligophrenin1 in Mice Impairs Spatial Memory and Leads to Ventricular Enlargement and Dendritic Spine Immaturity

Loss of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar hypoplasia and, in some cases, with lateral ventricle enlargement. In vitro studies showed that ophn1 regulates dendritic spine through the control of Rho GTPases, but its in vivo function r...

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Publicat a:J Neurosci
Autors principals: Khelfaoui, Malik, Denis, Cécile, van Galen, Elly, de Bock, Frédéric, Schmitt, Alain, Houbron, Christophe, Morice, Elise, Giros, Bruno, Ramakers, Ger, Fagni, Laurent, Chelly, Jamel, Nosten-Bertrand, Marika, Billuart, Pierre
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2007
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6673114/
https://ncbi.nlm.nih.gov/pubmed/17728457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2029-07.2007
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