Fatty acid desaturase 1 knockout mice are lean with improved glycemic control and decreased development of atheromatous plaque

Delta-5 desaturase (D5D) and delta-6 desaturase (D6D), encoded by fatty acid desaturase 1 (FADS1) and FADS2 genes, respectively, are enzymes in the synthetic pathways for ω3, ω6, and ω9 polyunsaturated fatty acids (PUFAs). Although PUFAs appear to be involved in mammalian metabolic pathways, the phy...

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Bibliographic Details
Published in:Diabetes Metab Syndr Obes
Main Authors: Powell, David R, Gay, Jason P, Smith, Melinda, Wilganowski, Nathaniel, Harris, Angela, Holland, Autumn, Reyes, Maricela, Kirkham, Laura, Kirkpatrick, Laura L, Zambrowicz, Brian, Hansen, Gwenn, Platt, Kenneth A, van Sligtenhorst, Isaac, Ding, Zhi-Ming, Desai, Urvi
Format: Artigo
Language:Inglês
Published: Dove Medical Press 2016
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922822/
https://ncbi.nlm.nih.gov/pubmed/27382320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DMSO.S106653
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