High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes

Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening (HTS) data for 3 762 distinct global gene knockout (KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies....

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Veröffentlicht in:Bone Res
Hauptverfasser: Brommage, Robert, Liu, Jeff, Hansen, Gwenn M, Kirkpatrick, Laura L, Potter, David G, Sands, Arthur T, Zambrowicz, Brian, Powell, David R, Vogel, Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4472125/
https://ncbi.nlm.nih.gov/pubmed/26273529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/boneres.2014.34
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