Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model

Although Notch signaling is deregulated in prostate cancer, the role of this pathway in disease development and progression is not fully understood. Here, we analyzed 2 human prostate cancer data sets and found that higher Notch signaling correlates with increased metastatic potential and worse dise...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Kwon, Oh-Joon, Zhang, Li, Wang, Jianghua, Su, Qingtai, Feng, Qin, Zhang, Xiang H.F., Mani, Sendurai A., Paulter, Robia, Creighton, Chad J., Ittmann, Michael M., Xin, Li
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922719/
https://ncbi.nlm.nih.gov/pubmed/27294523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84637
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