Phosphorylation state–dependent modulation of spinal glycine receptors alleviates inflammatory pain

Diminished inhibitory neurotransmission in the superficial dorsal horn of the spinal cord is thought to contribute to chronic pain. In inflammatory pain, reductions in synaptic inhibition occur partially through prostaglandin E(2)- (PGE(2)-) and PKA-dependent phosphorylation of a specific subtype of...

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Pubblicato in:J Clin Invest
Autori principali: Acuña, Mario A., Yévenes, Gonzalo E., Ralvenius, William T., Benke, Dietmar, Di Lio, Alessandra, Lara, Cesar O., Muñoz, Braulio, Burgos, Carlos F., Moraga-Cid, Gustavo, Corringer, Pierre-Jean, Zeilhofer, Hanns Ulrich
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922714/
https://ncbi.nlm.nih.gov/pubmed/27270175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI83817
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