GABA interneurons mediate the rapid antidepressant-like effects of scopolamine

Major depressive disorder (MDD) is a recurring psychiatric illness that causes substantial health and socioeconomic burdens. Clinical reports have revealed that scopolamine, a nonselective muscarinic acetylcholine receptor antagonist, produces rapid antidepressant effects in individuals with MDD. Pr...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Wohleb, Eric S., Wu, Min, Gerhard, Danielle M., Taylor, Seth R., Picciotto, Marina R., Alreja, Meenakshi, Duman, Ronald S.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922686/
https://ncbi.nlm.nih.gov/pubmed/27270172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI85033
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