GABA interneurons are the cellular trigger for ketamine’s rapid antidepressant actions

A single subanesthetic dose of ketamine, an NMDA receptor (NMDAR) antagonist, produces rapid and sustained antidepressant actions in depressed patients, addressing a major unmet need for the treatment of mood disorders. Ketamine produces a rapid increase in extracellular glutamate and synaptic forma...

詳細記述

保存先:
書誌詳細
出版年:J Clin Invest
主要な著者: Gerhard, Danielle M., Pothula, Santosh, Liu, Rong-Jian, Wu, Min, Li, Xiao-Yuan, Girgenti, Matthew J., Taylor, Seth R., Duman, Catharine H., Delpire, Eric, Picciotto, Marina, Wohleb, Eric S., Duman, Ronald S.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Clinical Investigation 2020
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269589/
https://ncbi.nlm.nih.gov/pubmed/31743111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI130808
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