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Hepatitis B Virus-Induced Parkin-Dependent Recruitment of Linear Ubiquitin Assembly Complex (LUBAC) to Mitochondria and Attenuation of Innate Immunity

Hepatitis B virus (HBV) suppresses innate immune signaling to establish persistent infection. Although HBV is a DNA virus, its pre-genomic RNA (pgRNA) can be sensed by RIG-I and activates MAVS to mediate interferon (IFN) λ synthesis. Despite of the activation of RIG-I-MAVS axis by pgRNA, the underly...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Khan, Mohsin, Syed, Gulam Hussain, Kim, Seong-Jun, Siddiqui, Aleem
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922663/
https://ncbi.nlm.nih.gov/pubmed/27348524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005693
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