Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

Renal fibrosis is the final, common pathway of end-stage renal disease. Whether and how autophagy contributes to renal fibrosis remains unclear. Here we first detected persistent autophagy in kidney proximal tubules in the renal fibrosis model of unilateral ureteral obstruction (UUO) in mice. UUO-as...

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Detalhes bibliográficos
Publicado no:Autophagy
Main Authors: Livingston, Man J., Ding, Han-Fei, Huang, Shuang, Hill, Joseph A., Yin, Xiao-Ming, Dong, Zheng
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
Assuntos:
Basic Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922446/
https://ncbi.nlm.nih.gov/pubmed/27123926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1166317
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