Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction

Renal fibrosis is the final, common pathway of end-stage renal disease. Whether and how autophagy contributes to renal fibrosis remains unclear. Here we first detected persistent autophagy in kidney proximal tubules in the renal fibrosis model of unilateral ureteral obstruction (UUO) in mice. UUO-as...

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Vydáno v:Autophagy
Hlavní autoři: Livingston, Man J., Ding, Han-Fei, Huang, Shuang, Hill, Joseph A., Yin, Xiao-Ming, Dong, Zheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2016
Témata:
Basic Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922446/
https://ncbi.nlm.nih.gov/pubmed/27123926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2016.1166317
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