Single-cell analysis of glandular T cell receptors in Sjögren’s syndrome

CD4(+) T cells predominate in salivary gland (SG) inflammatory lesions in Sjögren’s syndrome (SS). However, their antigen specificity, degree of clonal expansion, and relationship to clinical disease features remain unknown. We used multiplex reverse-transcriptase PCR to amplify paired T cell recept...

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Udgivet i:JCI Insight
Main Authors: Joachims, Michelle L., Leehan, Kerry M., Lawrence, Christina, Pelikan, Richard C., Moore, Jacen S., Pan, Zijian, Rasmussen, Astrid, Radfar, Lida, Lewis, David M., Grundahl, Kiely M., Kelly, Jennifer A., Wiley, Graham B., Shugay, Mikhail, Chudakov, Dmitriy M., Lessard, Christopher J., Stone, Donald U., Scofield, R. Hal, Montgomery, Courtney G., Sivils, Kathy L., Thompson, Linda F., Farris, A. Darise
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922426/
https://ncbi.nlm.nih.gov/pubmed/27358913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85609
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