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Single-cell analysis of glandular T cell receptors in Sjögren’s syndrome

CD4(+) T cells predominate in salivary gland (SG) inflammatory lesions in Sjögren’s syndrome (SS). However, their antigen specificity, degree of clonal expansion, and relationship to clinical disease features remain unknown. We used multiplex reverse-transcriptase PCR to amplify paired T cell recept...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Joachims, Michelle L., Leehan, Kerry M., Lawrence, Christina, Pelikan, Richard C., Moore, Jacen S., Pan, Zijian, Rasmussen, Astrid, Radfar, Lida, Lewis, David M., Grundahl, Kiely M., Kelly, Jennifer A., Wiley, Graham B., Shugay, Mikhail, Chudakov, Dmitriy M., Lessard, Christopher J., Stone, Donald U., Scofield, R. Hal, Montgomery, Courtney G., Sivils, Kathy L., Thompson, Linda F., Farris, A. Darise
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922426/
https://ncbi.nlm.nih.gov/pubmed/27358913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.85609
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