EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen

Chordoma is a rare malignant bone tumour with a poor prognosis and limited therapeutic options. We undertook a focused compound screen (FCS) against 1097 compounds on three well‐characterized chordoma cell lines; 154 compounds were selected from the single concentration screen (1 µm), based on their...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Scheipl, Susanne, Barnard, Michelle, Cottone, Lucia, Jorgensen, Mette, Drewry, David H, Zuercher, William J, Turlais, Fabrice, Ye, Hongtao, Leite, Ana P, Smith, James A, Leithner, Andreas, Möller, Peter, Brüderlein, Silke, Guppy, Naomi, Amary, Fernanda, Tirabosco, Roberto, Strauss, Sandra J, Pillay, Nischalan, Flanagan, Adrienne M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2016
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Original Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922416/
https://ncbi.nlm.nih.gov/pubmed/27102572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4729
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