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Generation of Novel, Secreted Epidermal Growth Factor Receptor (EGFR/ErbB1) Isoforms Via Metalloprotease-Dependent Ectodomain Shedding and Exosome Secretion

Exosomes are small membrane vesicles derived from intracellular multivescicular bodies (MVBs) that can undergo constitutive and regulated secretion from cells. Exosomes can also secrete soluble proteins through metalloprotease-dependent ectodomain shedding. In this study, we sought to determine whet...

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Detalhes bibliográficos
Publicado no:J Cell Biochem
Main Authors: Sanderson, Michael P., Keller, Sascha, Alonso, Angel, Riedle, Svenja, Dempsey, Peter J., Altevogt, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922250/
https://ncbi.nlm.nih.gov/pubmed/17910038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.21569
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