APE1/Ref-1 facilitates recovery of gray and white matter and neurological function after mild stroke injury

A major hallmark of oxidative DNA damage after stroke is the induction of apurinic/apyrimidinic (AP) sites and strand breaks. To mitigate cell loss after oxidative DNA damage, ischemic cells rapidly engage the base excision-repair proteins, such as the AP site-repairing enzyme AP endonuclease-1 (APE...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Stetler, R. Anne, Gao, Yanqin, Leak, Rehana K., Weng, Zhongfang, Shi, Yejie, Zhang, Lili, Pu, Hongjian, Zhang, Feng, Hu, Xiaoming, Hassan, Sulaiman, Ferguson, Carolyn, Homanics, Gregg E., Cao, Guodong, Bennett, Michael V. L., Chen, Jun
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2016
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PNAS Plus
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922172/
https://ncbi.nlm.nih.gov/pubmed/27274063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1606226113
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