Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging

Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important rol...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Wang, Rui-Hong, Zhao, Tingrui, Cui, Kairong, Hu, Gangqing, Chen, Qiang, Chen, Weiping, Wang, Xin-Wei, Soto-Gutierrez, Alejandro, Zhao, Keji, Deng, Chu-Xia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922021/
https://ncbi.nlm.nih.gov/pubmed/27346580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28633
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