Histone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells

The high proliferation rate of embryonic stem cells (ESCs) is thought to arise partly from very low expression of p21. However, how p21 is suppressed in ESCs has been unclear. We found that p53 binds to the p21 promoter in human ESCs (hESCs) as efficiently as in differentiated human mesenchymal stem...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Itahana, Yoko, Zhang, Jinqiu, Göke, Jonathan, Vardy, Leah A., Han, Rachel, Iwamoto, Kozue, Cukuroglu, Engin, Robson, Paul, Pouladi, Mahmoud A., Colman, Alan, Itahana, Koji
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921813/
https://ncbi.nlm.nih.gov/pubmed/27346849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28112
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