Transglutaminase 2 contributes to a TP53-induced autophagy program to prevent oncogenic transformation

Genetic alterations which impair the function of the TP53 signaling pathway in TP53 wild-type human tumors remain elusive. To identify new components of this pathway, we performed a screen for genes whose loss-of-function debilitated TP53 signaling and enabled oncogenic transformation of human mamma...

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Udgivet i:eLife
Main Authors: Yeo, Shi Yun, Itahana, Yoko, Guo, Alvin Kunyao, Han, Rachel, Iwamoto, Kozue, Nguyen, Hung Thanh, Bao, Yi, Kleiber, Kai, Wu, Ya Jun, Bay, Boon Huat, Voorhoeve, Mathijs, Itahana, Koji
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Genes and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4798945/
https://ncbi.nlm.nih.gov/pubmed/26956429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07101
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