Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation

OBJECTIVE: Insulin signaling plays pivotal roles in the development and metabolism of many tissues and cell types. A previous study demonstrated that ablation of insulin receptor (IR) with aP2-Cre markedly reduced adipose tissues mass and protected mice from obesity. However, multiple studies have d...

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Dades bibliogràfiques
Publicat a:Mol Metab
Autors principals: Qiang, Guifen, Whang Kong, Hyerim, Xu, Shanshan, Pham, Hoai An, Parlee, Sebastian D., Burr, Aaron A., Gil, Victoria, Pang, Jingbo, Hughes, Amy, Gu, Xuejiang, Fantuzzi, Giamila, MacDougald, Ormond A., Liew, Chong Wee
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921803/
https://ncbi.nlm.nih.gov/pubmed/27408774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.05.005
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