Lipodystrophy and severe metabolic dysfunction in mice with adipose tissue-specific insulin receptor ablation

OBJECTIVE: Insulin signaling plays pivotal roles in the development and metabolism of many tissues and cell types. A previous study demonstrated that ablation of insulin receptor (IR) with aP2-Cre markedly reduced adipose tissues mass and protected mice from obesity. However, multiple studies have d...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Qiang, Guifen, Whang Kong, Hyerim, Xu, Shanshan, Pham, Hoai An, Parlee, Sebastian D., Burr, Aaron A., Gil, Victoria, Pang, Jingbo, Hughes, Amy, Gu, Xuejiang, Fantuzzi, Giamila, MacDougald, Ormond A., Liew, Chong Wee
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921803/
https://ncbi.nlm.nih.gov/pubmed/27408774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.05.005
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