Effects of CYP3A5 polymorphism on the pharmacokinetics of a once-daily modified-release tacrolimus formulation and acute kidney injury in hematopoietic stem cell transplantation

BACKGROUND: Tacrolimus is metabolized by cytochrome P450 (CYP) 3A4 and 3A5. We investigated the influence of CYP3A5 polymorphism and concurrent use of azole antifungal agents (AZ) on the pharmacokinetics of a once-daily modified-release tacrolimus formulation (Tac-QD) in patients after hematopoietic...

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Veröffentlicht in:Cancer Chemother Pharmacol
Hauptverfasser: Yamashita, Takaya, Fujishima, Naohito, Miura, Masatomo, Niioka, Takenori, Abumiya, Maiko, Shinohara, Yoshinori, Ubukawa, Kumi, Nara, Miho, Fujishima, Masumi, Kameoka, Yoshihiro, Tagawa, Hiroyuki, Hirokawa, Makoto, Takahashi, Naoto
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4921119/
https://ncbi.nlm.nih.gov/pubmed/27217047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-016-3060-4
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