Baeyer-Villager monooxygenases EthA and MymA are required for activation of inhibitors against replicating and non-replicating Mycobacterium tuberculosis

Successful treatment of Mycobacterium tuberculosis infection typically requires a complex regimen administered over at least six months. Interestingly, many of the antibiotics used to treat M. tuberculosis are prodrugs that require intracellular activation. Here, we describe three small molecules, a...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Grant, Sarah Schmidt, Wellington, Samantha, Kawate, Tomohiko, Desjardins, Christopher A., Silvis, Melanie R., Wivagg, Carl, Thompson, Matthew, Gordon, Katherine, Kazyanskaya, Edward, Nietupski, Raymond, Haseley, Nathan, Iwase, Noriaki, Earl, Ashlee M., Fitzgerald, Michael, Hung, Deborah T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920728/
https://ncbi.nlm.nih.gov/pubmed/27321573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.05.011
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