Baeyer-Villager monooxygenases EthA and MymA are required for activation of inhibitors against replicating and non-replicating Mycobacterium tuberculosis

Successful treatment of Mycobacterium tuberculosis infection typically requires a complex regimen administered over at least six months. Interestingly, many of the antibiotics used to treat M. tuberculosis are prodrugs that require intracellular activation. Here, we describe three small molecules, a...

詳細記述

保存先:
書誌詳細
出版年:Cell Chem Biol
主要な著者: Grant, Sarah Schmidt, Wellington, Samantha, Kawate, Tomohiko, Desjardins, Christopher A., Silvis, Melanie R., Wivagg, Carl, Thompson, Matthew, Gordon, Katherine, Kazyanskaya, Edward, Nietupski, Raymond, Haseley, Nathan, Iwase, Noriaki, Earl, Ashlee M., Fitzgerald, Michael, Hung, Deborah T.
フォーマット: Artigo
言語:Inglês
出版事項: 2016
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920728/
https://ncbi.nlm.nih.gov/pubmed/27321573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.05.011
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