Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

OBJECTIVE: Acute pancreatitis is caused by toxins that induce acinar cell calcium overload, zymogen activation, cytokine release and cell death, yet is without specific drug therapy. Mitochondrial dysfunction has been implicated but the mechanism not established. DESIGN: We investigated the mechanis...

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Опубликовано в: :Gut
Главные авторы: Mukherjee, Rajarshi, Mareninova, Olga A, Odinokova, Irina V, Huang, Wei, Murphy, John, Chvanov, Michael, Javed, Muhammad A, Wen, Li, Booth, David M, Cane, Matthew C, Awais, Muhammad, Gavillet, Bruno, Pruss, Rebecca M, Schaller, Sophie, Molkentin, Jeffery D, Tepikin, Alexei V, Petersen, Ole H, Pandol, Stephen J, Gukovsky, Ilya, Criddle, David N, Gukovskaya, Anna S, Sutton, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: BMJ Publishing Group 2016
Предметы:
Pancreas
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920725/
https://ncbi.nlm.nih.gov/pubmed/26071131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2014-308553
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