Reprogrammable CRISPR/Cas9-based system for inducing site-specific DNA methylation

Advances in sequencing technology allow researchers to map genome-wide changes in DNA methylation in development and disease. However, there is a lack of experimental tools to site-specifically manipulate DNA methylation to discern the functional consequences. We developed a CRISPR/Cas9 DNA methyltr...

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Dettagli Bibliografici
Pubblicato in:Biol Open
Autori principali: McDonald, James I., Celik, Hamza, Rois, Lisa E., Fishberger, Gregory, Fowler, Tolison, Rees, Ryan, Kramer, Ashley, Martens, Andrew, Edwards, John R., Challen, Grant A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists Ltd 2016
Soggetti:
Methods & Techniques
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4920199/
https://ncbi.nlm.nih.gov/pubmed/27170255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.019067
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