Tumor Necrosis Factor-stimulated Gene 6 (TSG-6)-mediated Interactions with the Inter-α-inhibitor Heavy Chain 5 Facilitate Tumor Growth Factor β1 (TGFβ1)-dependent Fibroblast to Myofibroblast Differentiation

Fibroblasts are central to wound healing and fibrosis through TGFβ1-triggered differentiation into contractile, α-smooth muscle actin (α-SMA)-positive myofibroblasts. This is mediated by accumulation of a pericellular matrix of hyaluronan (HA) and the HA-dependent co-localization of CD44 with the ep...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Martin, John, Midgley, Adam, Meran, Soma, Woods, Emma, Bowen, Timothy, Phillips, Aled O., Steadman, Robert
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Glycobiology and Extracellular Matrices
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919461/
https://ncbi.nlm.nih.gov/pubmed/27143355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.670521
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