Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin

Abnormalities in parvalbumin (PV)-expressing interneurons cause neurodevelopmental disorders such as epilepsy, autism, and schizophrenia. Unlike other types of neurons that can be efficiently differentiated from pluripotent stem cells, PV neurons were minimally generated using a conventional differe...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Shi, Zixiao, Zhang, Juan, Chen, Shuangquan, Li, Yanxin, Lei, Xuepei, Qiao, Huimin, Zhu, Qianwen, Hu, Baoyang, Zhou, Qi, Jiao, Jianwei
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2016
נושאים:
Cell Biology
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919442/
https://ncbi.nlm.nih.gov/pubmed/27137935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709808
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