Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin

Abnormalities in parvalbumin (PV)-expressing interneurons cause neurodevelopmental disorders such as epilepsy, autism, and schizophrenia. Unlike other types of neurons that can be efficiently differentiated from pluripotent stem cells, PV neurons were minimally generated using a conventional differe...

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Foilsithe in:J Biol Chem
Main Authors: Shi, Zixiao, Zhang, Juan, Chen, Shuangquan, Li, Yanxin, Lei, Xuepei, Qiao, Huimin, Zhu, Qianwen, Hu, Baoyang, Zhou, Qi, Jiao, Jianwei
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2016
Ábhair:
Cell Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919442/
https://ncbi.nlm.nih.gov/pubmed/27137935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709808
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