Conversion of Fibroblasts to Parvalbumin Neurons by One Transcription Factor, Ascl1, and the Chemical Compound Forskolin

Abnormalities in parvalbumin (PV)-expressing interneurons cause neurodevelopmental disorders such as epilepsy, autism, and schizophrenia. Unlike other types of neurons that can be efficiently differentiated from pluripotent stem cells, PV neurons were minimally generated using a conventional differe...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Shi, Zixiao, Zhang, Juan, Chen, Shuangquan, Li, Yanxin, Lei, Xuepei, Qiao, Huimin, Zhu, Qianwen, Hu, Baoyang, Zhou, Qi, Jiao, Jianwei
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919442/
https://ncbi.nlm.nih.gov/pubmed/27137935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.709808
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