Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia(1)

The objective of our study was to determine the mechanism of action of the short-chain ceramide analog, C6-ceramide, and the breast cancer drug, tamoxifen, which we show coactively depress viability and induce apoptosis in human acute myelogenous leukemia cells. Exposure to the C6-ceramide-tamoxifen...

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Vydáno v:J Lipid Res
Hlavní autoři: Morad, Samy A. F., Ryan, Terence E., Neufer, P. Darrell, Zeczycki, Tonya N., Davis, Traci S., MacDougall, Matthew R., Fox, Todd E., Tan, Su-Fern, Feith, David J., Loughran, Thomas P., Kester, Mark, Claxton, David F., Barth, Brian M., Deering, Tye G., Cabot, Myles C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2016
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918852/
https://ncbi.nlm.nih.gov/pubmed/27140664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M067389
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