Parp-2 is required to maintain hematopoiesis following sublethal γ-irradiation in mice

Hematopoietic stem cells self-renew for life to guarantee the continuous supply of all blood cell lineages. Here we show that Poly(ADP-ribose) polymerase-2 (Parp-2) plays an essential role in hematopoietic stem/progenitor cells (HSPC) survival under steady-state conditions and in response to stress....

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Farrés, Jordi, Martín-Caballero, Juan, Martínez, Carlos, Lozano, Juan J., Llacuna, Laura, Ampurdanés, Coral, Ruiz-Herguido, Cristina, Dantzer, Françoise, Schreiber, Valérie, Villunger, Andreas, Bigas, Anna, Yélamos, José
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918799/
https://ncbi.nlm.nih.gov/pubmed/23678004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-12-472845
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