Cysteine Cathepsin Inhibitors as Anti-Ebola Agents

The recent Ebola virus outbreak in western Africa highlights the need for novel therapeutics that target Ebola virus and other filoviruses. Filoviruses require processing by host cell-derived cysteine cathepsins for productive infection. Here we report the generation of a focused library of cysteine...

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Udgivet i:ACS Infect Dis
Main Authors: van der Linden, Wouter A., Schulze, Christopher J., Herbert, Andrew S., Krause, Tyler B., Wirchnianski, Ariel A., Dye, John M., Chandran, Kartik, Bogyo, Matthew
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918641/
https://ncbi.nlm.nih.gov/pubmed/27347558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00130
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