Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension

Pulmonary arterial (PA) stiffness is associated with increased mortality in patients with pulmonary hypertension (PH); however, the role of PA stiffening in the pathogenesis of PH remains elusive. Here, we show that distal vascular matrix stiffening is an early mechanobiological regulator of experim...

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Veröffentlicht in:JCI Insight
Hauptverfasser: Liu, Fei, Haeger, Christina Mallarino, Dieffenbach, Paul B., Sicard, Delphine, Chrobak, Izabela, Coronata, Anna Maria F., Velandia, Margarita M. Suárez, Vitali, Sally, Colas, Romain A., Norris, Paul C., Marinković, Aleksandar, Liu, Xiaoli, Ma, Jun, Rose, Chase D., Lee, Seon-Jin, Comhair, Suzy A.A., Erzurum, Serpil C., McDonald, Jacob D., Serhan, Charles N., Walsh, Stephen R., Tschumperlin, Daniel J., Fredenburgh, Laura E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918638/
https://ncbi.nlm.nih.gov/pubmed/27347562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86987
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