Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension

Pulmonary arterial (PA) stiffness is associated with increased mortality in patients with pulmonary hypertension (PH); however, the role of PA stiffening in the pathogenesis of PH remains elusive. Here, we show that distal vascular matrix stiffening is an early mechanobiological regulator of experim...

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Publicat a:JCI Insight
Autors principals: Liu, Fei, Haeger, Christina Mallarino, Dieffenbach, Paul B., Sicard, Delphine, Chrobak, Izabela, Coronata, Anna Maria F., Velandia, Margarita M. Suárez, Vitali, Sally, Colas, Romain A., Norris, Paul C., Marinković, Aleksandar, Liu, Xiaoli, Ma, Jun, Rose, Chase D., Lee, Seon-Jin, Comhair, Suzy A.A., Erzurum, Serpil C., McDonald, Jacob D., Serhan, Charles N., Walsh, Stephen R., Tschumperlin, Daniel J., Fredenburgh, Laura E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918638/
https://ncbi.nlm.nih.gov/pubmed/27347562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86987
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