Distal vessel stiffening is an early and pivotal mechanobiological regulator of vascular remodeling and pulmonary hypertension

Pulmonary arterial (PA) stiffness is associated with increased mortality in patients with pulmonary hypertension (PH); however, the role of PA stiffening in the pathogenesis of PH remains elusive. Here, we show that distal vascular matrix stiffening is an early mechanobiological regulator of experim...

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發表在:JCI Insight
Main Authors: Liu, Fei, Haeger, Christina Mallarino, Dieffenbach, Paul B., Sicard, Delphine, Chrobak, Izabela, Coronata, Anna Maria F., Velandia, Margarita M. Suárez, Vitali, Sally, Colas, Romain A., Norris, Paul C., Marinković, Aleksandar, Liu, Xiaoli, Ma, Jun, Rose, Chase D., Lee, Seon-Jin, Comhair, Suzy A.A., Erzurum, Serpil C., McDonald, Jacob D., Serhan, Charles N., Walsh, Stephen R., Tschumperlin, Daniel J., Fredenburgh, Laura E.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918638/
https://ncbi.nlm.nih.gov/pubmed/27347562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.86987
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