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A C–H bond activation-based catalytic approach to tetrasubstituted chiral allenes

Enantioselective synthesis of fully substituted allenes has been a challenge due to the non-rigid nature of the axial chirality, which spreads over three carbon atoms. Here we show the commercially available simple Rh complex may catalyse the CMD (concerted metalation/deprotonation)-based reaction o...

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Pubblicato in:Nat Commun
Autori principali: Wu, Shangze, Huang, Xin, Wu, Wangteng, Li, Pengbin, Fu, Chunling, Ma, Shengming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918348/
https://ncbi.nlm.nih.gov/pubmed/26246391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8946
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