RNA-DNA Differences Are Generated in Human Cells within Seconds After RNA Exits Pol II

RNA sequences are expected to be identical to their corresponding DNA sequences. Here, we found all 12 types of RNA-DNA sequence differences (RDDs) in nascent RNA. Our results show that RDDs begin to occur in RNA chains about 55 nucleotides from the RNA polymerase II (Pol II) active site. These RDDs...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Wang, Isabel X., Core, Leighton J., Kwak, Hojoong, Brady, Lauren, Bruzel, Alan, McDaniel, Lee, Richards, Allison L., Wu, Ming, Grunseich, Christopher, Lis, John T., Cheung, Vivian G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4918108/
https://ncbi.nlm.nih.gov/pubmed/24561252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.01.037
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