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Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis
Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch-Russell branches. Following lanosterol, sterols of both branches are proposed to be dedicated to cholesterol. We challenge this dogma by mathematical modeling and with experimental evidence. It was not...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4917857/ https://ncbi.nlm.nih.gov/pubmed/27334049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28462 |
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