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Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis
Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch-Russell branches. Following lanosterol, sterols of both branches are proposed to be dedicated to cholesterol. We challenge this dogma by mathematical modeling and with experimental evidence. It was not...
Enregistré dans:
| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4917857/ https://ncbi.nlm.nih.gov/pubmed/27334049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28462 |
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