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Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis
Cholesterol synthesis is among the oldest metabolic pathways, consisting of the Bloch and Kandutch-Russell branches. Following lanosterol, sterols of both branches are proposed to be dedicated to cholesterol. We challenge this dogma by mathematical modeling and with experimental evidence. It was not...
Guardado en:
| Publicado en: | Sci Rep |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4917857/ https://ncbi.nlm.nih.gov/pubmed/27334049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28462 |
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