Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

Two zoonotic coronaviruses (CoVs)—SARS-CoV and MERS-CoV—have crossed species to cause severe human respiratory disease. Here, we showed that induction of airway memory CD4(+) T cells specific for a conserved epitope shared by SARS-CoV and MERS-CoV is a potential strategy for developing pan-coronavir...

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Bibliografiske detaljer
Udgivet i:Immunity
Main Authors: Zhao, Jincun, Zhao, Jingxian, Mangalam, Ashutosh K., Channappanavar, Rudragouda, Fett, Craig, Meyerholz, David K., Agnihothram, Sudhakar, Baric, Ralph S., David, Chella S., Perlman, Stanley
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Inc. 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917442/
https://ncbi.nlm.nih.gov/pubmed/27287409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.05.006
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