Lipopolysaccharide-induced binding of receptor CD300b to Toll-like receptor 4 alters signaling to drive lethal cytokine responses that enhance septic shock

Receptor CD300b is implicated in regulating the immune response to bacterial infection by an unknown mechanism. Here, we identified CD300b as an lipopolysaccharide (LPS)-binding receptor and determined the mechanism underlying CD300b augmentation of septic shock. In vivo depletion and adoptive trans...

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Publicado no:Immunity
Main Authors: Voss, Oliver H., Murakami, Yousuke, Pena, Mirna Y., Lee, Ha-Na, Tian, Linjie, Margulies, David H., Street, Jonathan M., Yuen, Peter S. T., Qi, Chen-Feng, Krzewski, Konrad, Coligan, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4917413/
https://ncbi.nlm.nih.gov/pubmed/27261276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.05.005
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