p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

Apoptotic cell (AC) clearance is essential for immune homeostasis. Here we show that mouse CD300f (CLM-1) recognizes outer membrane-exposed phosphatidylserine, and regulates the phagocytosis of ACs. CD300f accumulates in phagocytic cups at AC contact sites. Phosphorylation within CD300f cytoplasmic...

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Autors principals: Tian, Linjie, Choi, Seung-Chul, Murakami, Yousuke, Allen, Joselyn, Morse, Herbert C., Qi, Chen-Feng, Krzewski, Konrad, Coligan, John E
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151829/
https://ncbi.nlm.nih.gov/pubmed/24477292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4146
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