p85α recruitment by the CD300f phosphatidylserine receptor mediates apoptotic cell clearance required for autoimmunity suppression

Apoptotic cell (AC) clearance is essential for immune homeostasis. Here we show that mouse CD300f (CLM-1) recognizes outer membrane-exposed phosphatidylserine, and regulates the phagocytosis of ACs. CD300f accumulates in phagocytic cups at AC contact sites. Phosphorylation within CD300f cytoplasmic...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tian, Linjie, Choi, Seung-Chul, Murakami, Yousuke, Allen, Joselyn, Morse, Herbert C., Qi, Chen-Feng, Krzewski, Konrad, Coligan, John E
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4151829/
https://ncbi.nlm.nih.gov/pubmed/24477292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4146
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