Hyperleptinemia is associated with impaired pulmonary host defense

We have previously reported that obesity attenuates pulmonary inflammation in both patients with acute respiratory distress syndrome (ARDS) and in mouse models of the disease. We hypothesized that obesity-associated hyperleptinemia, and not body mass per se, drives attenuation of the pulmonary infla...

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Publicado en:JCI Insight
Main Authors: Ubags, Niki D.J., Stapleton, Renee D., Vernooy, Juanita H.J., Burg, Elianne, Bement, Jenna, Hayes, Catherine M., Ventrone, Sebastian, Zabeau, Lennart, Tavernier, Jan, Poynter, Matthew E., Parsons, Polly E., Dixon, Anne E., Wargo, Matthew J., Littenberg, Benjamin, Wouters, Emiel F.M., Suratt, Benjamin T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916854/
https://ncbi.nlm.nih.gov/pubmed/27347561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.82101
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