Hyperleptinemia is associated with impaired pulmonary host defense

We have previously reported that obesity attenuates pulmonary inflammation in both patients with acute respiratory distress syndrome (ARDS) and in mouse models of the disease. We hypothesized that obesity-associated hyperleptinemia, and not body mass per se, drives attenuation of the pulmonary infla...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Ubags, Niki D.J., Stapleton, Renee D., Vernooy, Juanita H.J., Burg, Elianne, Bement, Jenna, Hayes, Catherine M., Ventrone, Sebastian, Zabeau, Lennart, Tavernier, Jan, Poynter, Matthew E., Parsons, Polly E., Dixon, Anne E., Wargo, Matthew J., Littenberg, Benjamin, Wouters, Emiel F.M., Suratt, Benjamin T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4916854/
https://ncbi.nlm.nih.gov/pubmed/27347561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.82101
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