A TRAF-like motif of ICOS controls development of germinal center T follicular helper cells via TBK1

Inducible costimulator (ICOS) signaling fuels the stepwise development of T follicular helper (T(FH)) cells. However, a signaling pathway unique to ICOS has not been identified. We show that TANK-binding kinase 1 (TBK1) associates with ICOS via a conserved motif, IProx, which shares homology with tu...

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Publicado no:Nat Immunol
Main Authors: Pedros, Christophe, Zhang, Yaoyang, Hu, Joyce K., Choi, Youn Soo, Canonigo-Balancio, Ann J, Yates, John R., Altman, Amnon, Crotty, Shane, Kong, Kok-Fai
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915981/
https://ncbi.nlm.nih.gov/pubmed/27135603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3463
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