Integrative genome analyses identify key somatic driver mutations of small cell lung cancer

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor survival(1–3). We sequenced 29 SCLC exomes, two genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million basepairs. Therefore, we conducted integrated analyses o...

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發表在:Nat Genet
Main Authors: Peifer, Martin, Fernández-Cuesta, Lynnette, Sos, Martin L, George, Julie, Seidel, Danila, Kasper, Lawryn H, Plenker, Dennis, Leenders, Frauke, Sun, Ruping, Zander, Thomas, Menon, Roopika, Koker, Mirjam, Dahmen, Ilona, Müller, Christian, Di Cerbo, Vincenzo, Schildhaus, Hans-Ulrich, Altmüller, Janine, Baessmann, Ingelore, Becker, Christian, de Wilde, Bram, Vandesompele, Jo, Böhm, Diana, Ansén, Sascha, Gabler, Franziska, Wilkening, Ines, Heynck, Stefanie, Heuckmann, Johannes M, Lu, Xin, Carter, Scott L, Cibulskis, Kristian, Banerji, Shantanu, Getz, Gad, Park, Kwon-Sik, Rauh, Daniel, Grütter, Christian, Fischer, Matthias, Pasqualucci, Laura, Wright, Gavin, Wainer, Zoe, Russell, Prudence, Petersen, Iver, Chen, Yuan, Stoelben, Erich, Ludwig, Corinna, Schnabel, Philipp, Hoffmann, Hans, Muley, Thomas, Brockmann, Michael, Engel-Riedel, Walburga, Muscarella, Lucia A, Fazio, Vito M, Groen, Harry, Timens, Wim, Sietsma, Hannie, Thunnissen, Erik, Smit, Egbert, Heideman, Daniëlle AM, Snijders, Peter JF, Cappuzzo, Federico, Ligorio, Claudia, Damiani, Stefania, Field, John, Solberg, Steinar, Brustugun, Odd Terje, Lund-Iversen, Marius, Sänger, Jörg, Clement, Joachim H, Soltermann, Alex, Moch, Holger, Weder, Walter, Solomon, Benjamin, Soria, Jean-Charles, Validire, Pierre, Besse, Benjamin, Brambilla, Elisabeth, Brambilla, Christian, Lantuejoul, Sylvie, Lorimier, Philippe, Schneider, Peter M, Hallek, Michael, Pao, William, Meyerson, Matthew, Sage, Julien, Shendure, Jay, Schneider, Robert, Büttner, Reinhard, Wolf, Jürgen, Nürnberg, Peter, Perner, Sven, Heukamp, Lukas C, Brindle, Paul K, Haas, Stefan, Thomas, Roman K
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915822/
https://ncbi.nlm.nih.gov/pubmed/22941188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2396
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