Integrative genome analyses identify key somatic driver mutations of small cell lung cancer

Small-cell lung cancer (SCLC) is an aggressive lung tumor subtype with poor survival(1–3). We sequenced 29 SCLC exomes, two genomes and 15 transcriptomes and found an extremely high mutation rate of 7.4±1 protein-changing mutations per million basepairs. Therefore, we conducted integrated analyses o...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Genet
Egile Nagusiak: Peifer, Martin, Fernández-Cuesta, Lynnette, Sos, Martin L, George, Julie, Seidel, Danila, Kasper, Lawryn H, Plenker, Dennis, Leenders, Frauke, Sun, Ruping, Zander, Thomas, Menon, Roopika, Koker, Mirjam, Dahmen, Ilona, Müller, Christian, Di Cerbo, Vincenzo, Schildhaus, Hans-Ulrich, Altmüller, Janine, Baessmann, Ingelore, Becker, Christian, de Wilde, Bram, Vandesompele, Jo, Böhm, Diana, Ansén, Sascha, Gabler, Franziska, Wilkening, Ines, Heynck, Stefanie, Heuckmann, Johannes M, Lu, Xin, Carter, Scott L, Cibulskis, Kristian, Banerji, Shantanu, Getz, Gad, Park, Kwon-Sik, Rauh, Daniel, Grütter, Christian, Fischer, Matthias, Pasqualucci, Laura, Wright, Gavin, Wainer, Zoe, Russell, Prudence, Petersen, Iver, Chen, Yuan, Stoelben, Erich, Ludwig, Corinna, Schnabel, Philipp, Hoffmann, Hans, Muley, Thomas, Brockmann, Michael, Engel-Riedel, Walburga, Muscarella, Lucia A, Fazio, Vito M, Groen, Harry, Timens, Wim, Sietsma, Hannie, Thunnissen, Erik, Smit, Egbert, Heideman, Daniëlle AM, Snijders, Peter JF, Cappuzzo, Federico, Ligorio, Claudia, Damiani, Stefania, Field, John, Solberg, Steinar, Brustugun, Odd Terje, Lund-Iversen, Marius, Sänger, Jörg, Clement, Joachim H, Soltermann, Alex, Moch, Holger, Weder, Walter, Solomon, Benjamin, Soria, Jean-Charles, Validire, Pierre, Besse, Benjamin, Brambilla, Elisabeth, Brambilla, Christian, Lantuejoul, Sylvie, Lorimier, Philippe, Schneider, Peter M, Hallek, Michael, Pao, William, Meyerson, Matthew, Sage, Julien, Shendure, Jay, Schneider, Robert, Büttner, Reinhard, Wolf, Jürgen, Nürnberg, Peter, Perner, Sven, Heukamp, Lukas C, Brindle, Paul K, Haas, Stefan, Thomas, Roman K
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2012
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Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4915822/
https://ncbi.nlm.nih.gov/pubmed/22941188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.2396
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