Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity.
Mutations were identified in the catalytic subunit (C) of the cAMP-dependent protein kinase (EC 2.7.1.37) that block inactivation by regulatory subunit (R) without compromising catalytic activity. Randomly mutagenized mouse C expression vectors were screened functionally for clones that stimulated g...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1992
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49156/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1584809/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.10.4726 |
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