Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase.

The cAMP-dependent protein kinase (PKA) has been shown to play an important role in long-term potentiation (LTP) in the hippocampus, but little is known about the function of PKA in long-term depression (LTD). We have combined pharmacologic and genetic approaches to demonstrate that PKA activity is...

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Bibliographic Details
Main Authors:	Brandon, E P, Zhuo, M, Huang, Y Y, Qi, M, Gerhold, K A, Burton, K A, Kandel, E R, McKnight, G S, Idzerda, R L
Format:	Artigo
Language:	Inglês
Published:	1995
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC41065/ https://ncbi.nlm.nih.gov/pubmed/7568030
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Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase.

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